Dr. John Castle is an expert in computational biology and the Chief Data Scientist at Monte Rosa Therapeutics. John enjoys integrating AI/ML, computational immunology, bioinformatics, biotechnology, and genomics. Having built translational bioinformatics and genomics units focused on immunotherapies, John pioneered ‘omics and computational approaches to neoantigen identification for anti-tumor immunity, revolutionizing neoantigen vaccine platforms, TCR target identification and I-O response biomarkers.
Prior to joining Monte Rosa, he was Associate Vice President for Translational Sciences at Agenus, served as associate director at Rosetta Inpharmatics/Merck & Co. and co-directed the Biomarker Development Center of Translational Oncology at the University of Mainz, Germany. John built the bioinformatics and genomics department at BioNTech AG.
John studied physics at Rice University in Houston and at the University of Göttingen in Germany, was a Fulbright Scholar at the Australian National University in Canberra and received his Ph.D. in geophysics from the University of Washington in Seattle.